Structural identifiability and observability of tumour growth models with and without chemotherapy
DOI:
https://doi.org/10.17979/ja-cea.2025.46.12194Palabras clave:
modelos matemáticos, modelos dinámicos, biología matemática, oncología matemática, crecimiento tumoral, quimioterapiaResumen
En este trabajo se presenta una guía de modelos mecanísticos para el estudio del crecimiento tumoral, basados en ecuaciones diferenciales ordinarias (EDOs). El análisis se centra en las propiedades de identificabilidad estructural y observabilidad, fundamentales para la estimación de parámetros y la obtención de predicciones fiables. Se analizan modelos representativos que incluyen procesos sin terapia y con quimioterapia. Se ofrecen resultados agrupados por tipo de modelo, proporcionando una visión general sobre su aplicabilidad y limitaciones. Esta guía está pensada como apoyo para la selección de modelos en aplicaciones biomédicas.
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Derechos de autor 2025 Adriana González Vázquez, Alejandro F. Villaverde
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
