Estudio preliminar: caracterización por ultrasonido de criogeles de PVA
DOI:
https://doi.org/10.17979/ja-cea.2026.47.13723Palabras clave:
PVA, propilenglicol, criogel, phantom, ultrasonido, velocidad del sonido, tejidos blandosResumen
Los materiales miméticos de tejido son herramientas fundamentales para la calibración, validación y entrenamiento en técnicas de ultrasonido, al permitir reproducir condiciones experimentales controladas y comparables con tejidos biológicos. En este trabajo se fabricaron criogeles de alcohol polivinílico (PVA) con distintas concentraciones de propilenglicol, incorporado como aditivo mediante sustitución parcial del agua desmineralizada, con el objetivo de ajustar su respuesta acústica. Las muestras se obtuvieron por gelificación física mediante ciclos de congelación-descongelación y fueron caracterizadas en inmersión, a 36,5 ºC, mediante transductores de ultrasonido. A partir del análisis de los tiempos de vuelo se determinó la velocidad longitudinal del sonido en cada formulación. Los resultados mostraron velocidades medias comprendidas entre 1578,5 y 1615,7 m/s tras el quinto ciclo, valores compatibles con los reportados para diversos tejidos blandos. Estos hallazgos constituyen resultados preliminares para la selección de formulaciones y orientan el desarrollo de nuevas composiciones de PVA-propilenglicol con propiedades acústicas ajustables para aplicaciones biomédicas basadas en ultrasonido.
Referencias
Abdessamad, M., Iqdour, R., Ankrim, M., Zeroual, A., Benhayoun, M., Quotb, K., 01 2005. New model for speed of sound with temperature in pure water. AMSE Review (Association for the Advancement of Modelling and Simulation Techniques in Enterprises) 74, 12.10–12.13.
Arteaga-Marrero, N., Villa, E., González-Fernández, J., Martín, Y., Ruiz-Alzola, J., Llanos-González, A. B., 2023. Low-cost pseudoanthropomorphic pva-c and cellulose lung phantom for ultrasound-guided interventions. Gels 9 (2), 74. DOI: 10.3390/gels9020074
Braunstein, L., Brüningk, S. C., Rivens, I., Civale, J., Ter Haar, G., 2022. Characterization of acoustic, cavitation, and thermal properties of poly (vinyl alcohol) hydrogels for use as therapeutic ultrasound tissue mimics. Ultrasound in Medicine & Biology 48 (6), 1095–1109.
Busqué Nadal, A., 2023. Ultrasonic characterization of graphite-doped resins. Trabajo fin de máster, Universidad Miguel Hernández de Elche, Elche, España.
Culjat, M. O., Goldenberg, D., Tewari, P., Singh, R. S., 2010. A review of tissue substitutes for ultrasound imaging. Ultrasound in medicine & biology 36 (6), 861–873.
Durham, P. G., Kuntz, H. L., Lal, A., Donnelly, E., 2022. Polyvinyl alcohol cryogels for acoustic characterization of tissue-mimicking materials. Ultrasound in Medicine & Biology 48 (6), 1196–1207. DOI: 10.1016/j.ultrasmedbio.2022.01.013
Elvira, L., Duran, C., Higuti, R. T., Tiago, M. M., Ibanez, A., Parrilla, M., Valverde, E., Jiménez, J., Bassat, Q., 2019. Development and characterization of medical phantoms for ultrasound imaging based on customizable and mouldable polyvinyl alcohol cryogel–based materials and 3-d printing: Application to high-frequency cranial ultrasonography in infants. Ultrasound in Medicine & Biology 45 (8), 2226–2241.
Gerald, A., et al., 2023. Soft optical sensor and haptic feedback system for robotic palpation. In: Proceedings of the IEEE/RSJ International Conference on Intelligent Robots and Systems.
He, P., Zheng, J., 2001. Acoustic dispersion and attenuation measurement using both transmitted and reflected pulses. Ultrasonics 39 (1), 27–32. DOI: 10.1016/S0041-624X(00)00037-8
Jawli, A., Aldehani, W., Nabi, G., Huang, Z., 2024. Tissue-mimicking material fabrication and properties for multiparametric ultrasound phantoms: a systematic review. Bioengineering 11 (6), 620.
Kim, M. G., et al., 2024. Recent advancements in high-frequency ultrasound: From imaging to stimulation. Sensors 24 (19), 6471. DOI: 10.3390/s24196471
Liang, X., et al., 2024. Polyvinyl alcohol (pva)-based hydrogels: Recent progress in biomedical applications. Polymers 16 (19), 2755. DOI: 10.3390/polym16192755
Liu,W., Li, D., Xie,W., 2025. A novel time-of-flight difference determination method for ultrasonic thickness measurement with ultrasonic echo onset point detection. Applied Acoustics 233, 110605. DOI: 10.1016/j.apacoust.2025.110605
Lu, Z., Yang, C., Qin, D., Luo, Y., Momayez, M., 2016. Estimating ultrasonic time-of-flight through echo signal envelope and modified gauss newton method. Measurement 94, 355–363. DOI: 10.1016/j.measurement.2016.08.013
Malone, A. J., Cournane, S., Naydenova, I. G., Fagan, A. J., Browne, J. E., 2020. Polyvinyl alcohol cryogel based vessel mimicking material for modelling the progression of atherosclerosis. Physica Medica 69, 1–8.
Mast, T. D., 2000. Empirical relationships between acoustic parameters in human soft tissues. Acoustics Research Letters Online 1 (2), 37–42.
Mencarelli, M., Puggelli, L., Virga, A., Furferi, R., Volpe, Y., 2024. Acoustic velocity and stability of tissue-mimicking echogenic materials for ultrasound training phantoms. Journal of Materials Science 59, 7232–7248. DOI: 10.1007/s10853-024-09610-8
Rodríguez, A., Svilainis, L., Dumbrava, V., Chaziachmetovas, A., Salazar, A., 2014. Automatic simultaneous measurement of phase velocity and thickness in composite plates using iterative deconvolution. Ndt & E International 66, 117–127.
Rodríguez-Martínez, A., de la Casa-Lillo, M. Á., Svilainis, L., Gomez Álvarez-Arenas, T. E., 2018. Characterization of nanoparticles doped composites using ultrasound. Ultrasonics 83, 68–79. DOI: 10.1016/j.ultras.2017.06.017
Sharma, A., Marapureddy, S. G., Paul, A., Bisht, S. R., Kakkar, M., Thareja, P., Mercado-Shekhar, K. P., 2023. Characterizing viscoelastic polyvinyl alcohol phantoms for ultrasound elastography. Ultrasound in Medicine & Biology 49 (2), 497–511.
Surry, K., Austin, H., Fenster, A., Peters, T., 2004. Poly (vinyl alcohol) cryogel phantoms for use in ultrasound and mr imaging. Physics in Medicine & Biology 49 (24), 5529–5546.
Svilainis, L., 2019. Review on time delay estimate subsample interpolation in frequency domain. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 66 (11), 1691–1698. DOI: 10.1109/TUFFC.2019.2926275
Villa, E., Arteaga-Marrero, N., Gonz´alez-Fern´andez, J., Ruiz-Alzola, J., 2020. Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging. Scientific reports 10 (1), 20401.
Zhong, Y., et al., 2024. Construction methods and biomedical applications of pva-based hydrogels. Frontiers in Chemistry 12, 1376799. DOI: 10.3389/fchem.2024.1376799
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Derechos de autor 2026 Juan Sebatián Montenegro-Bravo, Alberto Rodríguez-Martínez , Juan David Romero-Ante, Miguel Ángel de la Casa-Lillo, Jose María Sabater-Navarro

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.